Anti-Inflammatory Response of Mannose-Conjugated Polyrotaxane Endocytosed into Macrophage

Tomo Ehashi; Hoon Hyun; Nobuhiko Yui

Macromolecular Research, Vol.19, No.5, 495-500, May, 2011

DOI10.1007/s13233-011-0506-8 Export Citation

Anti-Inflammatory Response of Mannose-Conjugated Polyrotaxane Endocytosed into Macrophage

Tomo Ehashi¹, Hoon Hyun¹, and Nobuhiko Yui^{1, 2, †}

¹School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1, Asahi-dai, Nomi, Ishikawa, 923-1292, Japan
²JST, CREST, 5, Sanbancho, Chiyoda-ku, Tokyo, 102-0075, Japan

E-mail:

Macrophage response to mannose-conjugated polyrotaxane (Man-PRX) was examined in terms of the morphological changes in macrophage-like J774.1 cells and their inflammation-related cytokine expression. The results obtained were compared with those by mannose-conjugated α-CD (Man-CD), mannan, and mannose-conjugated polyacrylamide (Man-PAAm). The largest percentage of the morphological change was observed for Man-PRX, which is presumably induced by mannose receptor-mediated endocytosis. In the cytokine expression experiments, anti-inflammatory cytokine was expressed by Man-PRX but the pro-inflammatory cytokine level was increased by Man-PAAm. Therefore, Man-PRX has great potential as anti-inflammatory biomaterial.

Keywords:mannose-conjugated polyrotaxane;endocytosis;macrophage response.

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[2] Sandor M, Xu H, Connor J, Lombardi J, Harper JR, Silverman RP, McQuillan DJ, Tissue Eng., 14A, 2021 (2008)

[3] Ye Q, Harmsen MC, van Luyn MJA, Bank RA, Biomaterials, 31, 9192 (2010)

[4] Badylak SF, Valentin JE, Ravindra AK, McCabe GP, Stewart-Arkers AM, Tissue Eng., 14A, 1835 (2008)

[5] Kvist PH, Iburg T, Dawson HD, Jensen HE, Diabetes Technol. Ther., 12, 791 (2010)

[6] Brodbeck WG, Voskerician G, Ziats NP, Nakayama Y, Matsuda T, Anderson JM, J. Biomed. Mater. Res., 64A, 320 (2003)

[7] Rodriquez A, Meyerson H, Anderson JM, J. Biomed. Mater. Res., 89A, 152 (2009)

[8] Lammers G, Gilissen C, Nillesen STM, Uijtdewilligen PJE, Wismans RG, Veltman JA, Daamen WF, van Kuppevelt TH, Biomaterials, 31, 8299 (2010)

[9] Ishihara K, Ziats NP, Tierney BP, Nakabayashi N, Anderson JM, J. Biomed. Mater. Res., 25, 1397 (1991)

[10] Anderson JM, Rodriguez A, Chang DT, Semin. Immunol., 20, 86 (2008)

[11] Kamath S, Bhattacharyya D, Padukudru C, Timmons RB, Tang L, J. Biomed. Mater. Res., 86A, 617 (2008)

[12] Shen M, Garcia I, Maier RV, Horbett TA, J. Biomed. Mater. Res., 70A, 533 (2004)

[13] Ooya T, Eguchi M, Yui N, J. Am. Chem. Soc., 125(43), 13016 (2003)

[14] Park HD, Lee WK, Ooya T, Park KD, Kim YH, Yui N, J. Biomed. Mater. Res., 66A, 596 (2003)

[15] Yui N, Ooya T, Chem. Eur. J., 12, 6730 (2006)

[16] Gazi U, Martinez-Pomares L, Immunobiol., 214, 554 (2009)

[17] Aderem A, Underhill DM, Annu. Rev. Immunol., 17, 593 (1999)

[18] Stahl PD, Ezekowitz RAB, Curr. Opinion. Immunol., 10, 50 (1998)

[19] Hyun H, Yui N, Macromol. Rapid Commun., 32(3), 326 (2011)

[20] Hyun H, Yui N, Macromol. Biosci., in press (2011)., 11

[21] Hanessian S, Benalil A, Laferrere C, J. Org. Chem., 60, 4786 (1995)

[22] Porcaro I, Vidal M, Jouvert S, Stahl PD, Giaimis J, J. Leukoc. Biol., 74, 206 (2003)

[23] Mytar B, Gawlicka M, Szatanek R, Wołoszyn M, Ruggiero I, Piekarska B, Zembala M, Inflamm. Res., 53, 100 (2004)

[24] Diment S, Leech MS, Stahl PD, J. Leukoc. Biol., 42, 485 (1987)

[25] Fiani ML, Beitz J, Turvy D, Blum JS, Stahl PD, J. Leukoc. Biol., 64, 85 (1998)

[26] Brodbeck WG, Nakyama Y, Matsuda T, Colton E, Ziats NP, Anderson JM, Cytokine, 18, 311 (2002)

[27] Chang JR, Zaczynska E, Katsetos CD, Platsoucas CD, Oleszak EL, Virology, 278, 346 (2000)

[28] Dadsetan M, Jones JA, Hiltner A, Anderson JM, J. Biomed. Mater. Res., 71A, 439 (2004)

[29] Ohki K, Soejima T, Kohashi O, Nagayama A, Cell Struct. Funct., 16, 495 (1991)

[30] Martinez FO, Sica A, Mantovani A, Locati M, Front Biosci., 13, 453 (2008)