The enthalpies of solution of DL-alpha-alanyl-DL-alpha-asparagine(AlaAsn)were measured in aqueous methanol, ethanol, 1-propanol and 2-propanol with an alcohol mole-fraction content x(2) (from 0 to 0.4) at 298.15 K. The experimental results were used to calculate the enthalpies of transfer of AlaAsn from water to these mixtures as well as the enthalpy coefficients of pair-wise interactions (h(xy)) between AlaAsn and alcohol molecules in water, according to the McMillan-Mayer's model. The h(xy) values were found to be positive and increasing in a series methanol < ethanol < 1-propanol < 2-propanol. (C) 2010 Elsevier B.V. All rights reserved.