The present article gives a comparative account of the efficiency of carrier-free 90Y separation from 90Sr by solvent extraction, flat sheet-supported liquid membrane (FSSLM) and hollow fiber-supported liquid membrane (HFSLM) methods using bis(2-ethylhexyl) phosphonic acid (PC88A) as the carrier extractant. The major focus of this work has been to develop the HFSLM method for the separation of Y(III) on a relatively large scale. The feed and receiver phase conditions were optimized by carrying out batch solvent-extraction studies. The extraction of Sr(II) by PC88A was negligible in the acidity range of 0.01-3M HNO3, whereas the extraction of Y(III) was significantly large at lower acidity (0.1M HNO3) with a separation factor (SF=DY/DSr) of 8.5x104. HFSLM studies suggested selective and efficient transport of Y(III) into 3M HNO3 from a feed solution containing a mixture of Y(III) and Sr(II) at 0.1M HNO3. On the other hand, transport of Sr(II) was negligible in the receiver phase. The purity of the separated 90Y was ascertained by paper chromatography and by half-life measurement. The radiation stability of the carrier was excellent as studied up to 1000 KGy dose.