This paper describes two phase (solid particles/gas) flow in a supersonic nozzle that is part of a device for micromolecular vaccine/drug delivery. It accelerates micro solid particles to high speeds sufficient to penetrate the viable epidermis layer to achieve the pharmaceutical effect. Helium is used as the driving gas for the solid particles because of its high compressibility factor. A numerical parametric study was performed for gas pressures ranging between 3 and 6 MPa and gold particles of diameters 1.8 mu m and 5 mu m. The computed results show that uniform particle velocity was achieved at standoff distance of 2 exit diameters (D-e) downstream of the device exit with particles concentrated on the supersonic core jet. Increasing the helium pressure from 3 to 6 MPa caused an increase in the particle velocity of 24% for particles with a diameter of 1.8 mu m and 7% for particles of diameter 5 mu m at the standoff distance. Furthermore increased gas pressure has adverse effect on particles concentration. As the inlet pressure increases, the particles are concentrated more at the core of the nozzle. Semi-empirical particle penetration calculation confirms the numerical results that the 5 mu m particles penetration distance is 45-135 mu m and the 1.8 mu m diameter penetration is 35-95 mu m beneath the skin. Comparison of different geometries has been done in order to understand each section function and to gain optimum performance. (C) 2011 Elsevier B.V. All rights reserved.