Flow behavior of gas and solids is simulated in combination the gas-solid two-fluid model with a cluster structure-dependent (CSD) drag coefficient model. The dispersed phase is modeled by a Eulerian approach based upon the kinetic theory of granular flow (KTGF) including models for describing the dispersed phase interactions with the continuous phase. The drag forces of gas-solid phases are predicted from the local structure parameters of the dense and dilute phases based on the minimization of the energy consumed by heterogeneous drag. The cluster structure-dependent (CSD) drag coefficients are incorporated into the two-fluid model to simulate flow behavior of gas and particles in a riser. Simulation results indicate that the dynamic formation and dissolution of clusters can be captured with the cluster structure-dependent drag coefficient model. Simulated solid velocity and concentration of particles profiles are in reasonable agreement with experimental results. (C) 2010 Published by Elsevier B.V.