The ring-opening metathesis polymerization (ROMP) was used to develop a new class of block copolymers toward biological detection with signal amplification For this, duce classes of ROMP monomers were synthesized. (i) luminescent and electrochemilummescent Ii ansfflon-metal-contaming monomer s, with i uthemum, osmium, and iridium bipyridine units, 0 0 biologically compatible monomers and macromonomers containing oligothylene glycol units, and (m) bioconjugatable monomers as well as monomer s containing the biorecognn ion unit biotin ROMP was used to efficiently combine these monomer s into a mphiphilic di- and triblock copolymers Self-assembly of these block copolymers in aqueous media genermes micellal spherical assemblies, which contain a large number of luminescent transition-metal centels in their col e. a biocompatible and biologically inert protecting shell, and biological recognition units or bioconjuizatable groups on then periphery These micelles can act as luminescent markers for biological molecules with potential for signal amplification In addition, the monomers and polymers reported here can serve is useful biologically enabled building blocks for a number of applications, including drug delivery and tissue engineering