Smart delivery system for cosmetic ingredients using pH-sensitive polymer hydrogel particles

Eunmi Lee; Bumsang Kim

Korean Journal of Chemical Engineering, Vol.28, No.6, 1347-1350, June, 2011

DOI10.1007/s11814-010-0509-8 Export Citation

Smart delivery system for cosmetic ingredients using pH-sensitive polymer hydrogel particles

Eunmi Lee, and Bumsang Kim^†

Department of Chemical Engineering, Hongik University, 72-1 Sangsu-dong, Mapo-gu, Seoul 121-791, Korea

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pH-Sensitive P(MAA-co-EGMA) hydrogel microparticles were prepared and their feasibility as smart delivery carriers for cosmetically active ingredients such as arbutin, adenosine, and niacinamide was evaluated. P(MAAco-EGMA) hydrogel microparticles were synthesized via dispersion photopolymerization. There was a drastic change in the swelling ratio of P(MAA-co-EGMA) microparticles at a pH of around 5. The loading efficiency of the cosmetic ingredients was affected by the electrostatic interaction between the hydrogel and the cosmetic ingredients. The P(MAAco-EGMA) hydrogel microparticles showed a pH-sensitive release behavior. Thus, at pH 4 almost none of the cosmetic ingredients except adenosine permeated through the skin, while at pH 6 relatively high skin permeability was obtained. These results indicate that the P(MAA-co-EGMA) hydrogel microparticles synthesized in this study have the potential to be used as a smart carrier for cosmetic ingredients triggered by an external pH change for cosmetic applications.

Keywords:Hydrogel Microparticles;Cosmetic Ingredients;Arbutin;Adenosine;Niacinamide;pH-sensitive;Smart Delivery System;Skin Permeability

[References]

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Bissett DL, Clin. Dermatol., 27, 435 (2009)
Draelos ZD, Clin. Dermatol., 27, 431 (2009)
Lupo MP, Clin. Dermatol., 19, 467 (2001)
Farahmand S, Tajerzadeh H, Farboud ES, Pharm. Dev. Technol., 11, 255 (2006)
Kogan A, Garti N, Adv. Colloid Interf., 123, 369 (2006)
Lee SM, Jin BS, Appl. Chem., 8(1), 13 (2004)
Drulis-Kawa Z, Dorotkiewicz-Jach A, Int. J. Pharmaceut., 387, 187 (2010)
Agnely F, Djedour A, Bochot A, Grossiord JL, J. Drug Deliv. Sci. Tec., 16, 3 (2006)
Kim D, Jeong Y, Choi C, Roh S, Kang S, Jang M, Nah J, Int. J. Pharmaceut., 319, 1330 (2006)
Oh M, Lee J, Kim S, Kim S, Park K, Yun H, Baek K, Kwon N, Kim D, J. Soc. Cosmet. Scientists Korea., 35, 19 (2009)
Legendre JY, Schnitzler I, Li Q, Hausen C, Huart M, Luengo GS, Abella ML, Roreger M, J. Cosmet. Sci., 58, 147 (2007)
Sorg O, Antille C, Kaya G, Saurat HH, Dermatol. Ther., 19, 289 (2006)
Park CI, Shin MS, Kim H, Korean J. Chem. Eng., 25(3), 581 (2008)
Hong ES, Nguyen DTM, Nguyen DH, Kim EK, Korean J. Chem. Eng., 25(6), 1463 (2008)
Bissett DL, Miyamoto K, Sun P, Li J, Berge CA, Int. J. Cosmet. Sci., 26, 231 (2004)
Lin, H. Wu and Y. Huang Y, Anal. Chim. Acta., 581, 102 (2007)

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[1] Kaczvinsky JR, Grimes PE, J. Drugs Dermatol., 8, S15 (2009)

[2] Bissett DL, Clin. Dermatol., 27, 435 (2009)

[3] Draelos ZD, Clin. Dermatol., 27, 431 (2009)

[4] Lupo MP, Clin. Dermatol., 19, 467 (2001)

[5] Farahmand S, Tajerzadeh H, Farboud ES, Pharm. Dev. Technol., 11, 255 (2006)

[6] Kogan A, Garti N, Adv. Colloid Interf., 123, 369 (2006)

[7] Lee SM, Jin BS, Appl. Chem., 8(1), 13 (2004)

[8] Drulis-Kawa Z, Dorotkiewicz-Jach A, Int. J. Pharmaceut., 387, 187 (2010)

[9] Agnely F, Djedour A, Bochot A, Grossiord JL, J. Drug Deliv. Sci. Tec., 16, 3 (2006)

[10] Kim D, Jeong Y, Choi C, Roh S, Kang S, Jang M, Nah J, Int. J. Pharmaceut., 319, 1330 (2006)

[11] Oh M, Lee J, Kim S, Kim S, Park K, Yun H, Baek K, Kwon N, Kim D, J. Soc. Cosmet. Scientists Korea., 35, 19 (2009)

[12] Legendre JY, Schnitzler I, Li Q, Hausen C, Huart M, Luengo GS, Abella ML, Roreger M, J. Cosmet. Sci., 58, 147 (2007)

[13] Sorg O, Antille C, Kaya G, Saurat HH, Dermatol. Ther., 19, 289 (2006)

[14] Park CI, Shin MS, Kim H, Korean J. Chem. Eng., 25(3), 581 (2008)

[15] Hong ES, Nguyen DTM, Nguyen DH, Kim EK, Korean J. Chem. Eng., 25(6), 1463 (2008)

[16] Bissett DL, Miyamoto K, Sun P, Li J, Berge CA, Int. J. Cosmet. Sci., 26, 231 (2004)

[17] Lin, H. Wu and Y. Huang Y, Anal. Chim. Acta., 581, 102 (2007)