A novel thermally responsive copolymer p(NIPAAm-co-DEGDVE) is synthesized using the substrate independent method of iCVD and exhibits a sharp lower critical solution temperature (LCST) transition centered at approximate to 28.5 +/- 0.3 degrees C determined via quartz crystal microbalance measurements with dissipation monitoring (QCM-D). Swelling with water below the LCST produces a reversible change of approximate to 3 x in film thickness. The layer is conformal on nanostructured surfaces including MWCNT forests and electrospun nanofiber mats. Modified planar substrates exhibit approximate to 30 degrees change in static contact angle over the LCST, while through conformal coating on nanostructured substrates changes in static contact angle up to 135 degrees are achieved. Additionally, coated surfaces exhibit temperature sensitive BSA adsorption measured by QCM-D and is reversible as shown through fluorescence imaging of a coated electrospun nanofiber mat.