Journal of the American Chemical Society, Vol.133, No.11, 3780-3783, 2011
Rh(NHC)-Catalyzed Direct and Selective Arylation of Quinolines at the 8-Position
A new catalytic protocol for the regioselective direct arylation of quinoline derivatives at the 8-position has been developed. The reaction is catalyzed by a Rh(NHC) system, and the choice of the NHC ligand was most important for achieving high reactivity and selectivity.