화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.132, No.49, 17378-17380, 2010
Pd(II)-Catalyzed Carbonylation of C(sp(3))-H Bonds: A New Entry to 1,4-Dicarbonyl Compounds
Pd(II)-catalyzed beta-C(sp(3))-H carbonylation of N-arylamides under CO (1 atm) has been achieved. Following amide-directed C(sp(3))-H cleavage and insertion of CO into the resulting [Pd(II)-C(sp(3))] bond, intramolecular C-N reductive elimination gave the corresponding succinimides, which could be readily converted to 1,4-dicarbonyl compounds. This method was found to be effective with substrates containing alpha-hydrogen atoms and could be applied to effect methylene C(sp(3))-H carbonylation of cyclopropanes.