Journal of the American Chemical Society, Vol.132, No.21, 7260-7260, 2010
Asymmetric Deprotonation of N-Boc Piperidine: React IR Monitoring and Mechanistic Aspects
The high yielding asymmetric deprotonation trapping of N-Boc piperidine is successfully realized using s-BuLi and a (+)-sparteine surrogate. Monitoring of the lithiation by in situ React IR allowed the direct observation of a prelithiation complex.