Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog

Oskarsson T; Nagorny P; Krauss IJ; Perez L; Mandal M; Yang GL; Ouerfelli O; Xiao DH; Moore MAS; Massague J; Danishefsky SJ

Journal of the American Chemical Society, Vol.132, No.9, 3224-3228, 2010

Oskarsson T, Nagorny P, Krauss IJ, Perez L, Mandal M, Yang GL, Ouerfelli O, Xiao DH, Moore MAS, Massague J, Danishefsky SJ

A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells.