In biomaterial silane treated TiO2/high-density polyethylene(silane-TiO2/HDPE), silane connection structurally corresponds to acid phosphoprotein bond, which connects the noncalcified collagen fibril bands and the adjacent apatite crystals in natural bones. In order to explore the function and variation process of acid phosphoprotein under loading in natural bones, the microscopic variation mechanism of silane connection in silane-TiO2/HDPE was investigated through the compressive creep tests in air and saline solution. Through the analysis of creep rate curves under different stress loads, different creep mechanisms were proposed, in which silane connection plays a very important role. Through SEM observation of sample surfaces and the creep tests in saline solution, the important role of silane connection in creep process was further proved. That is, silane connection can not only support the loading stress but also hinder the failure process under loading effectively.