Melamine is commonly used to manufacture tableware, and this could be one of the important exposure sources in humans. The study aims to measure melamine migrated from different material-made tableware by the most sensitive technique of liquid chromatography-tandem mass spectrometry (LC-MS/MS). The test samples were filled with pre-warmed designated-temperature (from room temperature (similar to 20 degrees C), 30 degrees C, 40 degrees C, 50 degrees C, 60 degrees C, 70 degrees C, 80 degrees C, to 90 degrees C)simulant (either distilled water or 3% acetic acid) up to 20 ml and immersed in a water bath at that designated temperature for 15 or 30 minutes (min). High melamine migration levels, ranging from 6.97 to 19.03 mu g/ml, can be measured from all melamine-made samples containing 20 ml 3% acetic acid in water bath of 90 degrees C for 30 min, whereas melamine cannot be detectable in all other material-made samples in the same condition. In addition, the cheaper the melamine-made tableware samples, the higher the melamine migration levels, The migration of melamine amount is dependent on different temperatures, contact times, simulant, and prices of tableware. Since tableware is used in daily life, it is prudent to cautiously select materials that contain foodstuffs. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.