SrTiO3 hollow microspheres built by regular nanocubes were synthesized by a general and facile hydrothermal method. The resulting samples were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD) measurements. Owing to the special hollow structure, the synthesized SrTiO3 microspheres exhibit a superior photocatalytic activity in photoreduction of Cr(VI). As anatase and titanate contain common structural features, it makes this in situ phase transition from anatase to titanate relatively easy. Therefore, this method is rather convenient for controlling the morphology of the products by varying the presynthesized anatase TiO2 precursor. (c) 2011 Elsevier Inc. All rights reserved.