화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.28, No.4, 987-1008, April, 2011
DOI10.1007/s11814-011-0051-3  Export Citation
The principles and applications of nano-diagnosis system for a nano-biosensor
Jong Min Kim, Sang-Mok Chang, Hiroshi Muramatsu1, and Karube Isao1, †
  • Department of Chemical Engineering, Dong-A University, 840 hadan-dong, Saha-gu, Busan 604-714, Korea
  • 1Department of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1, Katakura, Hachioji, Tokyo 192-0982, Japan
E-mail:
In this review, the basic principles and research trends of biosensors are briefly described and a nano-sensing system applying QCM (quartz crystal micro-balance), nano-diagnosis methods by AFM (atomic force microscopy) and SNOAM (scanning near-field/atomic force microscopy) is discussed intensively. The principle, construction, and applications of piezoelectric crystal sensors as a universal sensor are reviewed. This review is focused mainly on liquid phase applications, such as immune-sensors, gelation detecting sensors, and cultured cell monitoring sensors. The principle of nano-diagnosis based on the AFM or SNOAM techniques is described in detail. Finally, the binding affinity of peptide probes to proteins using AFM and the visualizing of a hybridized PNA probe on a DNA molecule using SNOAM are evaluated and discussed.
Keywords:Biosensors;Nano-sensor;Quartz Crystal Microbalance;Nano-diagnosis;Scanning Probe Microscopy
  1. Clark LC, Lyons C, Ann. N.Y. Acad. Sci., 102, 29 (1962)
  2. Updike SJ, Hicks GP, Nature., 214, 986 (1967)
  3. Karube I, Suzuki S, Ion-Selective Electrode Reviews., 6, 15 (1984)
  4. Karube I, Ion-Selective Electrode Reviews., 10(1), 37 (1988)
  5. Gotoh M, Tamiya E, Momoi M, Kagawa Y, Karube I, Anal. Lett., 20, 857 (1987)
  6. Muramatsu H, Dicks JM, Karube I, Anal. Chim. Acta., 197, 347 (1987)
  7. Hayashi H, Sasaki S, Ikebukuro K, Karube I, Anal. Chim. Acta., 197, 127 (1996)
  8. Muramatsu H, Dicks JM, Anal. Chem., 59, 2760 (1987)
  9. Lim T, Oyama M, Ikebukuro K, Karube I, Anal. Chem., 72(13), 2856 (2000)
  10. Wu GH, Datar RH, Hansen KM, Thundat T, Cote RJ, Majumdar A, Nature Biotechnology., 19(9), 856 (2001)
  11. Arntz Y, Seeling JD, Lang HP, Zhang P, Ramseyer JP, Mayer E, Hegner M, Gerver M, Nanotechnology., 19, 856 (2003)
  12. Nakamura H, Karube I, Anal. Bioanal. Chem., 377(3), 446 (2003)
  13. Turner APF, Karube I, Wilson GS, Biosenssors - Fundamentals and applications., Oxford University Press, New York (1987)
  14. Karube I, Array technologies - Handbook of biosensors and biochips., John Wiley & Sons, New York, 857 (2007)
  15. Takeuchi T, Yoshida M, Kabasawa Y, Tamiya E, Karube I, Anal. Lett., 26, 1535 (1993)
  16. Song MI, Iwata K, Yamada M, Yokoyama K, Takeuchi T, Tamiya E, Karube I, Anal. Chem., 66, 778 (1994)
  17. Yokoyama K, Ikebukuro K, Tamiya E, Karube I, Ichiki N, Arikawa Y, Anal. Chim. Acta., 304, 139 (1995)
  18. Yagiuda K, Hemmi A, Ito S, Asano Y, Fushinuki Y, Chen CY, Karube I, Biosens. Bioelectron., 11, 703 (1996)
  19. Karube I, Nakanishi K, Current Opinion in Biotechnol., 5, 54 (1994)
  20. Nakamura H, Hirata Y, Mogi Y, Kobayashi S, Suzuki K, Hirayama T, Karube I, Anal. Bioanal. Chem., 389, 835 (2007)
  21. Karube I, Matsunaga T, Tsuru S, Suzuki S, Biochim. Biophys. Acta., 444, 338 (1976)
  22. Takeuchi T, Yokoyama K, Kobayashi K, Suzuki M, Tamiya E, Karube I, Utsunomiya K, Imai O, Masuda Y, Anal. Chim. Acta., 276, 65 (1993)
  23. Tuerk C, Gold L, Science., 249, 505 (1990)
  24. Nimjee SM, Annu. Rev. Med., 56, 555 (2005)
  25. Schena M, Shalon D, Davis RW, Brown PO, Science, 270(5235), 467 (1995)
  26. Chee M, Yang R, Hubbell E, Berno A, Huang XC, Stern D, Winkler J, Lockhart DJ, Morris MS, Fodor SP, Science, 274(5287), 610 (1996)
  27. Marshall E, Science., 291, 396 (2001)
  28. Terry SC, Jeman H, Angell JB, IEEE Trans. Electron Devices., 26, 1880 (1979)
  29. Manz A, Graber N, Widmer HM, Sens. Actuators. B., 1, 244 (1990)
  30. Blaws AS, Reichert WM, Biomaterials., 19, 575 (1998)
  31. Macbeath G, Schreiber SL, Science., 289, 1760 (2000)
  32. Zhu H, Bilgin M, Science., 293, 2101 (2001)
  33. Kukar T, Eckenrode S, Anal. Biochem., 306, 50 (2002)
  34. Kojima K, Hiratsuka A, Suzuki H, Yano K, Ikebukuro K, Karube I, Anal. Chem., 75, 1116 (2003)
  35. Jain KK, Clinica Chimica Acta., 358, 37 (2005)
  36. Matsubara Y, Murakami Y, Biosens. Bioelectron., 19, 741 (2004)
  37. Cui Y, Wei Q, Science., 293, 11298 (2001)
  38. Kim JP, Lee BY, Hong S, Sim SJ, Anal. Biochem., 381, 193 (2008)
  39. So HM, Won K, Kim YH, Kim BK, Ryu BH, Na PS, Kim H, Lee JO, J. Am. Chem. Soc., 127(34), 11906 (2005)
  40. Hahm J, Lieber CM, Nano Lett., 4(1), 51 (2004)
  41. Besteman K, Lee JO, Wiertz FGM, Heering HA, Dekker C, Nano Lett., 3(6), 727 (2003)
  42. Kurusu F, Tsunoda H, Saito A, Tomita A, Kadota A, Kayahara N, Karube I, Gotoh M, Analyst., 131(12), 1292 (2006)
  43. Chen RJ, Choi HC, Bangsaruntip S, Yenilmez E, Tang XW, Wang Q, Chang YL, Dai HJ, J. Am. Chem. Soc., 126(5), 1563 (2004)
  44. Jianrong C, Yuqing M, Biotechnology Advances., 22, 505 (2004)
  45. Vo-Dinh T, Appl. Spectr., 41, 735 (1987)
  46. Brian M, Anal. Biochem., 277, 25 (2000)
  47. Kasili PM, Vo-Dinh T, J. Nanosci. Nanotechnol., 5(12), 2057 (2005)
  48. Wabuyele MB, Vo-Dinh T, Anal. Chem., 77(23), 7810 (2005)
  49. Vo-Dinh T, Kasili P, Anal. Bioanal. Chem., 382(4), 918 (2005)
  50. Cao YC, Jin R, Science., 297, 1536 (2002)
  51. Nam JM, Stoeva SI, Mirkin CA, J. Am. Chem. Soc., 126(19), 5932 (2004)
  52. Stoeva SI, Lee JS, Shad T, Mirkin CA, Angew. Chem. Int. Ed., 45, 3303 (2006)
  53. Liu JW, Lu Y, J. Am. Chem. Soc., 125(22), 6642 (2003)
  54. Liu J, Lu Y, Nanotechnology., 14, 353 (2004)
  55. Star A, Tu E, Niemann J, PNAS., 103, 921 (2006)
  56. Park DW, Kim YH, Kim BS, So HM, Won K, Lee JO, Kong K, Chang H, J. Nanosci. Nanotechnol., 6, 3499 (2006)
  57. Brown R, Zellers ET, Enviromental monitoring., VCH Publishers Inc., New York, 529 (1989)
  58. Sauerbrey GZ, Zeitscrift fuer Physic., 155, 206 (1959)
  59. King WH, Anal. Chem., 36, 1735 (1964)
  60. Hlavay J, Guilbault G, Anal. Chem., 49, 1890 (1977)
  61. Kanazawa KK, Gordon JG, Anal. Chim. Acta., 175, 99 (1985)
  62. Muramatsu H, Tamiya E, Karube I, J. Membrane Sci., 41, 281 (1989)
  63. Muramatsu H, Tamiya E, Suzuki M, Anal. Chim. Acta., 215, 91 (1988)
  64. Muramatsu H, Tamiya E, Suzuki M, Karube I, Anal. Chim. Acta., 217, 321 (1989)
  65. Muramatsu H, Ye X, Suda M, Sakuhara T, Ataka T, Electroanal. Chem., 322, 311 (1992)
  66. Yufan H, Ying W, Guoyi Z, Erkang W, Electroanal. Chem., 440, 65 (1997)
  67. Orata D, Buttry DA, J. Am. Chem. Soc., 109, 3574 (1987)
  68. Kim JM, Chang SM, Muramatsu H, J. Electrochem. Soc., 146(12), 4544 (1999)
  69. Kim JM, Chang SM, Muramatsu H, Polymer, 40(12), 3291 (1999)
  70. Chang SM, Kim JM, Muramatsu H, Ataka T, Cho WJ, Ha CS, Polymer, 37(16), 3757 (1996)
  71. Kim JM, Chang SM, Muramatsu H, Appl. Phys. Lett., 74, 466 (1999)
  72. Kim JM, Park JY, Song SH, Muramatsu H, Lee BJ, Chang SM, Sens. Act. B., 76, 74 (2001)
  73. Kim JM, Kim SH, Ohashi T, Muramatsu H, Chang SM, Kim WS, Bioprocess Biosyst. Eng., 33, 39 (2010)
  74. Konash PL, Bastiaans G, Anal. Chem., 52, 1929 (1980)
  75. Lu CS, Lewis O, Appl. Phys., 43, 4385 (1972)
  76. Pulker HK, Benes E, Hammer D, Sollner E, Thin Solid Films., 32, 27 (1976)
  77. Glassford AP, Vac MJ, Sci. Technol., 75, 1836 (1978)
  78. Mecea V, Burcur V, Thin Solid Films., 60, 73 (1979)
  79. Crane RA, Fisher G, Appl. Phys. D., 12, 2019 (1979)
  80. Muramatsu H, Tamiya E, Karube I, Anal. Chem., 60, 2142 (1988)
  81. Muramatsu H, Kimura K, Anal.Chem., 64, 2502 (1992)
  82. Muramatsu H, Egawa A, Ataka T, J. Electroanal. Chem., 388(1-2), 89 (1995)
  83. Buttry DA, Ward MD, Chem. Rev., 92, 1355 (1992)
  84. Roederer JE, Bastiaans GJ, Anal. Chem., 55, 2333 (1983)
  85. Thompson M, Arthur CL, Dhaliwal GK, Anal. Chem., 58 (1988)
  86. Muramatsu H, Kajiwara K, Tamiya E, Karube I, Anal. Chim. Acta., 188, 257 (1986)
  87. Muramatsu, Y. Watanabe, M. Hikuma, T. Ataka, I. Kubo, Tamiya E, Karube I, Anal. Lett., 22, 2155 (1989)
  88. Okada T, Yamamoto Y, Miyachi H, Karube I, Muramatsu H, Biosens. Bioelectron., 22, 1480 (2007)
  89. Matsuoka H, Karube I, Nhung NTK, Suzuki S, Denki Kagaku., 50, 946 (1982)
  90. Matsuoka H, Tamiya E, Karube I, Anal. Chem., 57, 1998 (1985)
  91. Nisson K, Mosbach K, Biochem. Biophys. Res. Commun., 102, 449 (1981)
  92. Muramatsu H, Kimura K, Ataka T, Honma R, Miura Y, Karube I, Biosens. Bioelectron., 6, 32 (1991)
  93. Homma R, Takeda Y, Karube I, Kimura K, Muramatsu H, Anal. Biochem., 204, 398 (1992)
  94. Bang FB, Johns Hopkins Hosp., 98, 325 (1956)
  95. Levin J, Bang FB, Johns Hopkins Hosp., 115, 265 (1964)
  96. Nakamura S, Morita T, Harada-Suzuki T, Iwanaga S, Takahashi K, Niwa M, Biochem., 92, 781 (1982)
  97. Oishi H, Takaoka T, Hatayama Y, Matsuo T, Sakata Y, Parenter. Sci. Technol., 39, 194 (1985)
  98. Homma R, Pharm. Technol. Jpn., 1, 11 (1985)
  99. Chen CS, Mrksich M, Huang S, Whitesides GM, Ingber DE, Science, 276(5317), 1425 (1997)
  100. Flusberg DA, Numaguchi Y, Ingber DE, Mol. Biol., 12, 3087 (2001)
  101. Stamenovi D, Coughlin MF, Theor. Biol., 201, 63 (1999)
  102. Dubois JC, Souchier C, Couble ML, Exbrayat P, Lissac M, Biomaterials., 20, 1841 (1999)
  103. Morel FMM, Baker RF, Wayland H, Cell. Biol., 48, 91 (1971)
  104. O’Donovan DJ, Katkin JP, Tamura T, Husser R, Xu X, Smith CV, Welty SE, Am. J. Respir. Cell. Mol. Biol., 20, 256 (1999)
  105. Nomura K, Imai H, Koumura T, Arai M, Nakagawa Y, Biol. Chem., 274, 29294 (1999)
  106. Kang HW, Ida K, Yamamoto Y, Muramatsu H, Anal. Chim. Acta., 624, 154 (2008)
  107. Kang HW, Muramatsu H, Biosens. Bioelectron., 24, 1318 (2009)
  108. Binning G, Rohrer H, Gerber C, Weibel E, Phys. Rev. Lett., 49, 57 (1982)
  109. Binning G, Quate CF, Gerber C, Phys. Rev. Lett., 56, 930 (1986)
  110. Ohtani H, Wilson RJ, Chiang S, Mactec CM, Phys. Rev. Lett., 60, 2398 (1988)
  111. Smith DPE, Bryant A, Quate CF, Rabe JP, Gerber C, Swalen JD, Proc. Natl. Acad. Sci. USA., 84, 969 (1987)
  112. Foster JS, Frommer JE, Nature., 333, 542 (1988)
  113. Heckl WM, Smith DPE, Binnig HKG, Hansch TW, Maddocks J, Proc. Natl. Acad. Sci. USA., 88, 8003 (1991)
  114. Allen MJ, Balooch M, Subbiah S, Tench RJ, Siekhous W, Balhorn R, Scanning Microsc., 5, 625 (1991)
  115. Gould SAC, Marti O, Drake B, Hellemans L, Bracker CE, Hansma PK, Keder NL, Nature., 332, 332 (1988)
  116. Mou J, Sun W, Yan J, Yang WS, Liu C, Zhai Z, Xu Q, Xie Y, Vac. Sci. Technol., B9, 15569 (1991)
  117. Ruppersberg JP, Harber JKH, Gerber G, Binnig G, FEBS Letters., 257, 460 (1989)
  118. Guckenberger R, Hacker B, Hartmann T, Schubani T, Wang Z, Wiegrabe W, Baumeisyer W, Vac. Sci. Technol., B9, 1227 (1991)
  119. Zasadzinski JAN, Schneir J, Gurley J, Elings VB, Hansma PK, Science., 239, 1013 (1988)
  120. Singh S, Keller DJ, J. Biophys., 60, 1401 (1991)
  121. Lin JN, Drake B, Lea AS, Hansma PK, Andrade JD, Langmuir., 6, 509 (1990)
  122. Olk CH, Heremans J, Lee PS, Dziedzic D, Sargent NE, Vac. Sci. Technol., B9, 1628 (1991)
  123. Han S, Nakamura C, Imai Y, Nakamura N, Miyake J, Biosens. Bioelectron., 24, 1219 (2008)
  124. Han SW, Nakamura C, Obataya I, Nakamura N, Miyake J, Biochem. Biophys. Res. Commun., 332(3), 633 (2005)
  125. Han S, Nakamura C, Obataya I, Nakamura N, Miyake J, Biosens. Bioelectron., 20, 2120 (2005)
  126. Han S, Nakamura C, Obataya I, Nakamura N, Miyake J, Biosens. Bioelectron., 24, 1219 (2008)
  127. Han S, Nakamura C, Kotobuki N, Obataya I, Ohgushi H, Nagamune T, Miyake J, Nanomedicine., 4, 215 (2008)
  128. Nakamura C, Kamiishi H, Nakamura N, Miyake J, Electrochemistry., 76, 586 (2008)
  129. Obataya I, Nakamura C, Han S, Nakamura N, Miyake J, Nano Lett., 5, 27 (2005)
  130. Obataya I, Nakamura C, Han S, Nakamura N, Miyake J, Biosens. Bioelectron., 20, 1652 (2005)
  131. Obataya I, Nakamura C, Han S, Nakamura N, Miyake J, Nanobiotechnology., 1, 347 (2005)
  132. Wiesendanger R, Scanning probe microscopy and spectroscopy., Cambridge University Press, New York (1994)
  133. Hinterdorfer P, Dufrene YF, Nature Methods., 3(5), 347 (2006)
  134. Leckband D, Ann. Rev. Biophys. Biomol. Struct., 29, 126 (2000)
  135. Luckham PE, Smith K, Smith, Faraday Discuss., 111, 307 (1999)
  136. Park JW, Lee HY, Kim JM, Yamasaki R, Kanno T, Tanaka K, Tanaka H, Kawai T, J. Biosci. Bioeng., 97(1), 29 (2004)
  137. Kim JM, Jung HS, Park JW, Lee HY, Kawai T, Anal. Chim. Acta., 525, 151 (2004)
  138. Kim JM, Ohtani T, Park JY, Chang SM, Muramatsu H, Ultramicroscopy., 91, 139 (2002)
  139. Kim JM, Hirodse T, Sugiyama S, Ohtani T, Muramatsu H, Nano Lett., 4-11, 2091 (2004)
  140. Greulich KO, Chem. Phys. Chem., 6, 2458 (2005)
  141. Giessibl FJ, Mater. Today., 32 (2005)
  142. Withers JR, Aston DE, Adv. Collid Interf. Sci., 120, 57 (2006)
  143. Junno T, Carlsson SB, Xu H, Montelius L, Samuelson L, Appl. Phys. Lett., 72, 548 (1998)
  144. Okada Y, Amano S, Iuchi Y, Kawabe M, Harris JS, Electron. Lett., 34, 1262 (1998)
  145. Sasa S, Ikeda T, Dohno C, Inoue M, Japanese J. Appl. Phys., Part 1., 36, 4065 (1997)
  146. Sasa S, Yodogawa S, Ohya S, Inoue M, Japanese J. Appl. Phys., Part 1., 40, 2026 (2001)
  147. Campbell PM, Snow ES, McMarr PJ, Phys B: Condens Matter., 227, 315 (1996)
  148. Shirakashi JI, Matsumoto K, Miura N, Konagai M, Japanese J. Appl. Phys., Part 2., 36(9), 1257 (1997)
  149. Sosnowski RG, Tu E, Butler WF, O’Connell JP, Heller MJ, Proc. Natl. Acad. Sci. U.S.A., 94, 1119 (1997)
  150. Masarik M, Kizek R, Kramer KJ, Billova S, Brazdova M, Vacek J, Bailey M, Jelen F, Howard JA, Anal. Chem., 75, 2663 (2003)
  151. Caruso F, Rodda E, Furlong DN, Niikura K, Okahata Y, Anal. Chem., 69, 2043 (1994)
  152. Larsson C, Rodahl M, Hook F, Anal. Chem., 75, 2080 (2003)
  153. Wang J, Anal. Chim. Acta., 469, 63 (2002)
  154. Tamayo J, Garcia R, Langmuir, 12(18), 4430 (1996)
  155. Morris VJ, Kirby AR, Gunning AP, Atomic force microscopy for biologists., Imperial College Press, London (1999)
  156. Noort SJTV, Werf KOVD, Grooth BGD, Hulst NFV, Greve J, Ultramicroscopy., 69, 117 (1997)
  157. Argaman M, Golan R, Thomson NH, Hansma HG, Nucl. Acid. Res., 25, 4379 (1997)
  158. Cleveland JP, Anczykowski B, Schmid AE, Elings VB, Appl. Phys. Lett., 72, 2613 (1998)
  159. Fields S, Song O, Nature., 340, 245 (1989)
  160. Sekar RB, Periasamy A, Cell. Biol., 160, 629 (2003)
  161. Takeda S, Ptak A, Nakamura C, Miyake J, Kageshima M, Jarvis SP, Tokumoto H, Chem. Pharm. Bull., 49, 1512 (2001)
  162. Lehenkari PP, Horton MA, Biochem. Biophys. Res. Commun., 259, 645 (1999)
  163. Okada T, Sano M, Yamamoto Y, Muramatsu H, Langmuir, 24(8), 4050 (2008)
  164. Kim J, Yamasaki R, Park J, Jung H, Lee H, Kawai T, J. Biosci. Bioeng., 97(2), 138 (2004)
  165. Wang H, Bash R, Yodh JG, Hager GL, Lohr D, Lindsay SM, Biophys. J., 83, 3619 (2002)
  166. Hutter JL, Bechhoefer J, Rev. Sci. Instrum., 64, 1868 (1993)
  167. Lee HG, Fritsche E, Chromatogr., 994, 213 (2003)
  168. Green NM, Meth. Enzymol., 184, 51 (1990)
  169. Freitag S, Trong IL, Klumb LA, Chu V, Chilkoti A, Stayton PS, Stenkamp RE, Biomol. Eng., 16, 13 (1999)
  170. Engel A, Muller DJ, Nat. Struct. Biol., 7, 715 (2000)
  171. Durig UT, Pohl DW, Rohner F, Appl. Phys., 59, 3318 (1986)
  172. Heinzelmann H, Pohl DW, Appl. Phys., A59, 89 (1994)
  173. Foscher UC, Durig UT, Pohl DW, Appl. Phys. Lett., 52, 249 (1988)
  174. Reddick RC, Warmack RJ, Ferrell RL, Phys. Pev., B39, 767 (1989)
  175. Betzig E, Trautman JK, Science., 257 (1992)
  176. Shalom S, Lierman K, Lewis A, Sci. Instr., 63, 4061 (1992)
  177. vanHulst MF, Moers MHP, Noordman OFJ, Tack RG, Segerink FB, Bolger B, Appl. Phys. Lett., 62, 461 (1993)
  178. Muramatsu H, Chiba N, Umemoto T, Homma K, Nakajima K, Ataka T, Ohta S, Kusumi A, Fujihira M, Ultramicroscopy., 61, 265 (1995)
  179. Muramatsu H, Chiba N, Homma K, Nakajima K, Ataka T, Ohta S, Kusumi A, Fujigira M, Appl. Phys. Lett., 66, 3245 (1995)
  180. Chiba N, Muramatsu H, Ataka T, Fujihira M, Appl. Phys., 34, 321 (1995)
  181. Muramatsu H, Chiba N, Ataka T, Iwabuchi S, Nagatani N, Tamiya E, Fujihir M, Optical Review., 3, 470 (1996)
  182. Hansma PK, Cleveland JP, Radmacher M, Walters DA, Hillner PE, Bezanilla M, Fritz M, Vie D, Hansma HG, Appl. Phys. Lett., 64, 1738 (1994)
  183. Putman CAJ, Weft KOVD, Grooth BGD, Hulst NFV, Greve J, Appl. Phys. Lett., 64, 2454 (1994)
  184. Dreier M, Anselmetti D, Richmond T, Dammer U, Gfintherodt HJ, Appl. Phys., 76, 5095 (1994)
  185. Weirer HUG, Hitochem. Cytochem., 49, 939 (2001)
  186. Norio P, Schildkraut CL, Science., 294, 2361 (2001)
  187. Dunn RC, Chem. Rev., 99(10), 2891 (1999)
  188. Lewis A, Isaacson M, Harootunian A, Murray A, Ultramicroscopy., 13, 227 (1984)
  189. Pohl DW, Denk W, Lanz M, Appl. Phys. Lett., 44, 651 (1984)
  190. Bennink ML, Scharer OD, Lanaar R, Sakata-Sogawa K, Schins JM, Grooth BGD, Greve J, Cytometry., 36, 200 (1999)
  191. Kim JM, Muramatsu H, Lee HY, Kawai T, Febs Lett., 555, 611 (2003)
  192. Kim JM, Ohtani T, Muramatsu H, Surf. Sci., 549, 273 (2004)
  193. Kim JM, Ohtani T, Sugiyama S, Hirose T, Muramatsu H, Anal. Chem., 73, 5984 (2001)
  194. Yokota H, SunWoo J, Sarikaya M, Engh GVD, Aebersold R, Anal. Chem., 71, 4418 (1999)
  195. Demidov VV, Yavnilovich MV, Frank-Kamenetskii MD, Nielsen P, Proc. Natl. Acad. Sci. U.S.A., 92, 2637 (1995)
  196. Bukanov NO, Demidov VV, Nielsen PE, Frank-Kamenetskii MD, Proc. Natl. Acad. Sci. U.S.A., 95, 5516 (1998)
  197. Lohse J, Dahl O, Nielsen PE, Proc. Natl. Acad. Sci. U.S.A., 96, 11804 (1999)
  198. Muramatsu H, Homma K, Yamamoto N, Wang J, Mater. Sci. Eng. C., 12, 29 (2000)
  199. Wang J, Nucl. Acids Res., 28, 3011 (2000)
  200. Neidle S, Anti-cancer Drug Design., 12, 433 (1997)
  201. Ruddon RW, Cancer biology 3rd edition., Oxford University Press, New York (1995)
  202. Femino A, Fay FS, Fogarty K, Singer RH, Science, 280(5363), 585 (1998)
  203. Muramatsu H, Kim JM, Sugiyama S, Ohtani T, Rev. Sci. Instrum., 74, 100 (2003)