Large-eddy simulations using the flamelet models are applied to turbulent reacting liquid flows and validated by comparing with the experiments. The computations are performed for two reaction conditions, namely a rapid reaction and a moderately fast reaction in a grid-generated turbulent flow. For the flamelet models, both the steady flamelet model and the unsteady Lagrangian flamelet model are tested. A second-order, irreversible, and isothermal reaction is considered. The results show that the flamelet models inherently developed for turbulent combustion are applicable to turbulent reacting liquid flows, provided that the model coefficient in evaluating the subgrid scale variance of mixture fraction in the scale-similarity model is set to be 5.0. The rapid reaction can be adequately predicted by both the steady and unsteady Lagrangian flamelet models, whereas the moderately fast reaction can be predicted only by the unsteady Lagrangian flamelet model which is capable to take slow chemical processes into account. (C) 2010 American Institute of Chemical Engineers AIChE J, 57: 911-917, 2011