Efficient molecular mixing together is a key precondition for industrial exploitation of individual macromolecules for potential product development and quality assurance with resource saving mechanism. Conceptually, MFP (melamine-formaldehyde-polyvinylpyrrolidone) polymer resin was mixed with amino acids (L-lysine, L-tyrosine, L-proline, DL-alanine), nonionic surfactants (glycerol, orcinol), iodine as metal and cationic surfactants (DTAB, TMSOI) as dispersants, in 4 : 1 ratio, w/w. A mutual molecular dispersion occurs at a cost of molecular activities with utilization of a sufficient amount of activation energies. The activation energies (Delta mu(2)*, kJ mol(-1)) were derived from intrinsic viscosities ([eta], kg/L) and partial molar volumes ((V) over bar (2), 10(-6) m(3)/mol), which were calculated from experimental data of viscosities (eta, N s m(-2)) and apparent molar volumes (V-2, 10(-6) m(3)/mol) of 0.005, 0.007, 0.009, and 0.0011 g/mL aqueous samples of the dispersants at 304.15 K. The limiting data were fitted to standard activation energy equations and were analyzed to assess potential of their micromixing. Densities (p/10(3) kg m(-3)) for apparent molar volume (V-2/10(-6) m(3) mol(-1)) and viscosity (eta, 0.1N, s m(-2) = 0.1 kg m(-1) s(-1), = 1 poise, SI unit) were also measured with weight method. The Delta mu(2)*< 0, in arrange of -48.35 to -118.03 kJ/mol were noted that inferred effective micromixing evidenced with SEM images of the blends. The Delta mu(2)*, kJ mol(-1) data are as glycerol (-118.03) > TMSOI (-117.55) > DTAB (-102.93) > orcinol (-101.54) > MFP-R (-93.71) > iodine (-59.32) > L-proline (-59.27) > L-lysine (-55.87) > DL-alanine (-55.04) > L-tyrosine (-53.04) > water (-48.35) orders with maximum utilization of Delta mu(2)*, glycerol. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 118: 960-968,2010