In this article, operator-based robust nonlinear control system design for multi-input multi-output (MIMO) plants with unknown coupling effects is considered. That is, by using operator-based robust nonlinear control design, coupling effects existing in the MIMO nonlinear plants can be decoupled based on a feedback design and robust right coprime factorisation approach, the coupling effects caused by controllers and plant outputs can be stabilised by using definition of Lipschitz operator and contraction mapping theorem, and output tracking performance can be realised by a tracking design scheme. Finally, a simulation example about temperature control process of 3-input/3-output aluminum plate is given to support the theoretical analysis.