The aim of this work is to present a new experimental apparatus based on the static-analytic method suitable to perform solubility measurements of solids in sub- and supercritical carbon dioxide. Mole fractions of dissolved solids are determined online via high-performance liquid chromatography. The studied binary mixtures are capsaicin in carbon dioxide from 298 to 328 K, hexadecanoic acid in carbon dioxide at 313 and 318 K, beta-carotene in carbon dioxide at 298 and 313 K, and acetaminophen in carbon dioxide at 313 K. The experimental apparatus is also tested by circulating the fluid phase to measure the solubility of capsaicin in carbon dioxide at 298 K. Experimental solid solubilities in carbon dioxide are found to be in agreement with the solubility data reported in the literature. The Mendez-Santiago and Teja and the modified Chrastil models are used to correlate the experimental data.