Falling liquid film flow is a sort of ubiquitous transport phenomenon occurring in chemical engineering. Fundamental research on the flow and mass transfer behavior of falling liquid film flow on plates with different structures can help engineers to develop more, efficient equipment. In this paper, falling liquid film flow on a plate with rectangular holes is investigated with both numerical and experimental methods. Mass transfer experiments show that opening rectangle-shaped narrow holes on a plate can enhance the mass transfer efficiency. Compared to an ordinary plate, the vapor-liquid mass transfer rate on a holed plate can be increased by 10-20%. To analyze the detailed flow and mass transfer behavior, the computational fluid dynamics model (CFD) based on the volume of fluid (VOF) method is developed. In this model, the Marangoni effect induced by mass transfer is considered. The new model was demonstrated to give more satisfactory results than the previous model.