The heterogeneously catalyzed oxidation of glucose is performed in a rotor-stator spinning disk reactor. One side of the rotor is coated with a Pt/C and Nafion catalytic layer, resulting in a liquid-solid interfacial area of 274 m(i)(2) m(R)(-3). At the lowest rotational disk speed, 26 rad s(-1), the reaction is liquid-solid mass transfer limited; at the highest rotational disk speed, 180 rad s(-1), the intrinsic kinetics are rate determining. The experimental overall reaction rates are fitted with a resistances in series model, with the activation energy, pre-exponential factor, and volumetric liquid-solid mass transfer coefficient as parameters. The volumetric liquid-solid mass transfer coefficient, k(LS)a(LS), increases from 0.02 to 0.22 m(L)(3) mR(-3) s(-1) for a rotational disk speed of 26 to 157 rad These values are high in comparison to conventional reactors, like packed beds, in spite of the low liquid-solid interfacial area used in this study. The values of the liquid-solid mass transfer coefficient K-LS are I order of magnitude higher compared to values reported for packed beds. The Sherwood number for the liquid-solid mass transfer in the rotor-stator spinning disk reactor depends on the Reynolds number to the power 2 in the range 1 x 10(5) < Re < 7 x 10(5). In this range, the transition of laminar flow to turbulent flow takes place, resulting in a change of the mass transfer mechanism.