A dynamic model for a complete urea granulation circuit is presented in this work. The flowsheet includes a fluidized bed granulator, a cooling unit, a vibrating double-deck screen, and a double-roll crusher. This contribution is based on mathematical models for all the equipments, some of them previous validated against industrial data. All the units are modeled by means of the population balance equation (PBE). In addition, the granulator energy and mass balances for urea and air (used as a cooling medium and fluidization agent) are solved simultaneously with the PBE to properly represent the unit dynamics. Furthermore, mass, energy, and population balances are developed for the cooler. The individual units are successfully integrated under the gPROMS Model Builder Environment, which allows one to have a powerful tool for the circuit simulation and optimization. A sensitivity analysis is performed by running several dynamic and steady-state gPROMS simulations in order to evaluate the influence of different operating variables on the particle size distributions and mass flow rates of the circuit streams, as well as the mass holdup and thermal conditions in the granulator and cooler. The results indicate that both screen deck apertures, together with the crusher lower gap, are the variables that most affect the circuit performance. The circuit stability is also analyzed. Finally, different optimization scenarios are carried out to determine the values of the selected manipulated variables that maximize production on specification, minimize the recycle fraction, and allow a plant revamping. The urea granulation process simulator (including mass, energy, and population balances) constitutes a powerful tool to study the circuit responses under different disturbances, determine the optimal combination of operating and design variables in order to meet the production requirements and explore new process flow diagrams.