p-Hydroxyphenylacetic acids are used in the synthesis of pharmaceutical drugs such as atenolol betaxolol, or bufexamac. In this work, the indirect electrosynthesis of p-hydroxyphenylacetic acid is carried out using the redox system Cr(II)/Cr(III) as a mediator. Effluents that are not contaminated by chromium salts are obtained because the reductant, Cr(II), can be electrochemically regenerated. Voltammetric and galvanostatic studies were performed to find the best reaction conditions for the reduction of Cr(III) to Cr(II). An "ex-cell" procedure has been used for this process. Current efficiency, for Cr(II) synthesis, higher than 90% was reached using a bismuth-doped carbon-felt electrode. In the chemical reduction of the p-hydroxymandelic acid by electrochemically generated Cr(II), the presence of a cosolvent, reaction temperature, and molar Cr(II)/p-hydroxymandelic acid relationship was investigated. High material conversion and nearly quantitative yield was obtained at 90 degrees C using 2-propanol as the cosolvent.