In this communication, experimental dissociation data for methane hydrates in the presence of 0.042 mass fraction methanol aqueous Solution and/or 0.069 mass fraction ethylene glycol aqueous solution are first reported. The experimental data were generated using an isochoric pressure-search method. The experimental dissociation data for methane hydrates in the presence of 0.042 mass fraction methanol aqueous solution or 0.069 mass fraction ethylene glycol aqueous Solution are successfully compared with the predictions of a thermodynamic model to demonstrate its reliability for low concentrations of methanol or ethylene glycol in aqueous Solution. The model predictions are then compared with the experimental data for the methanol + ethylene glycol aqueous Solution system to Study its reliability. We finally report experimental dissociation data for methane hydrates in the presence of 0.1, 0.2, 0.35, and 0.5 mass fraction methanol or ethylene glycol aqueous Solutions with the aim of studying the reliability of corresponding experimental data reported in the literature and the predictions of the thermodynamic model.