Energy consumption in commercial buildings accounts for a significant proportion of worldwide energy consumption. Any increase in the energy efficiency of the energy systems for commercial buildings would lead to significant energy savings and emissions reductions. In this work, we introduce an energy systems engineering framework towards the optimal design of such energy systems with improved energy efficiency and environmental performance. The framework features a superstructure representation of the various energy technology alternatives, a mixed-integer optimization formulation of the energy systems design problem, and a multi-objective design optimization solution strategy, where economic and environmental criteria are simultaneously considered and properly traded off. A case study of a supermarket energy systems design is presented to illustrate the key steps and potential of the proposed energy systems engineering approach. (c) 2010 Elsevier Ltd. All rights reserved.