Anti-coagulating hydroxyethyl starch blended with hyaluronic acid as a novel post-surgical adhesion barrier

Jung Kyu Park; Junseok Yeom; Sei Kwang Hahn; Eui Jin Hwang; Jang Sik Shin; Il Hwan Cho; Suk Ho Bhang; Byung-Soo Kim

Macromolecular Research, Vol.18, No.11, 1076-1080, November, 2010

DOI10.1007/s13233-010-1103-y Export Citation

Anti-coagulating hydroxyethyl starch blended with hyaluronic acid as a novel post-surgical adhesion barrier

Jung Kyu Park, Junseok Yeom, Sei Kwang Hahn^†, Eui Jin Hwang¹, Jang Sik Shin¹, Il Hwan Cho¹, Suk Ho Bhang², and Byung-Soo Kim²

Department of Materials Science and Engineering, Pohang University of Science and Technology, Gyungbuk, 790-784, Korea
¹Biotechnology Department, Central Research Institute, Shinpoong Pharmaceutical Co., Gyeonggi, 425-100, Korea
²School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea

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Pharmacological and barrier-based approaches have been exploited for the treatment of post-surgical adhesion. In this study, anti-coagulating hydroxyethyl starch (HES) blended with hyaluronic acid (HA) was assessed as a novel post-surgical adhesion barrier in Sprague-Dawley (SD) rats to take advantage of both approaches. The HES/HA blend solution effectively reduced the adhesion area to 6.5% of the control, which might be due to the inhibited blood coagulation by HES as well as highly effective barrier properties of hygroscopic high molecular weight HA. Histological analysis showed that the HES/HA blend solutions effectively protected the smooth muscle cells and skeletal muscle cells from muscle degeneration by adhesion in the abdominal walls of SD rats.

Keywords:hydroxyethyl starch;hyaluronic acid;polymer blend;post-surgical adhesion barrier

[References]

Rogers KE, Dizerega GS, Peritoneal Surgery, Springer, New York, 2005.
Al-Musawi D, Thomson JN, Gynaecol. Endosc., 10, 123 (2001)
Kramer K, Senninger N, Herbst H, Probst W, Arch. Surg., 137, 278 (2002)
Reijen MM, Skrabut EM, Postma VA, Burns JW, van Goor H, J. Surg. Res., 101, 248 (2001)
De Iaco PA, Stefanetti M, Pressato D, Fertil. Steril., 69, 318 (1998)
Li Y, Prestwich GD, Fertil. Steril., 83, 1275 (2005)
Wei CZ, Hou CL, Gu QS, Jiang LX, Zhu B, Sheng AL, Biomaterials, 30, 5534 (2009)
Saribeyoglu K, Pekmezci S, Ulualp K, Arch. Surg., 139, 1380 (2004)
Dizerega GS, Peritoneum, Peritoneal Healing, and Adhesion Formation, Springer, New York, 2000.
Legrand EK, Rodgers KE, Girgis W, J. Surg. Res., 56, 67 (1994)
Guvenal T, Cetin A, Ozdemir H, Hum. Reprod., 16, 1732 (2001)
Chowdhury SM, Hubbell JA, J. Surg. Res., 61, 58 (1996)
Strauss RG, Stansfield C, Heriksen R, Transfusion, 28, 257 (1998)
Treib J, Haass A, Pindur G, Transfusion, 36, 450 (1996)
Barron ME, Wilkes MM, Navickis RJ, Arch. Surg., 139, 552 (2004)
Strauss RG, Stump DC, Henriksen RA, Transfusion, 25, 235 (1985)
Warren BB, Durieux ME, Anesth. Analg., 84, 206 (1997)
Yeo Y, Highly CB, Bellas E, Biomaterials, 27, 4698 (2006)
Oh EJ, Kang SW, Giang G, Cho IH, Hahn SK, J. Biomed. Mater. Res., 86A, 685 (2008)
Kim SJ, Hahn SK, Kim MJ, Kim DH, Lee YP, J. Control. Release, 104, 323 (2005)
Oh EJ, Kim JW, Kong JH, Ryu SH, Hahn SK, Bioconjugate Chem., 19, 2401 (2008)
Oh EJ, Park K, Choi JS, Joo CK, Hahn SK, Biomaterial, 30, 6026 (2009)
Jeon YS, Son YK, Hong KH, Kim JH, Macromol. Res., 16(4), 379 (2008)
Byun H, Hong B, Nam SY, Jung SY, Rhim JW, Lee SB, Moon GY, Macromol. Res., 16(3), 189 (2008)
Kang H, Ryu SH, Hahn SK, Oh EJ, Park JK, Kim KS, Macromol. Res., 16(2), 182 (2008)
Lee CM, Jeong HJ, Kim DW, Lee KY, Macromol. Res., 16(5), 429 (2008)

[Referenced By]

[1] Rogers KE, Dizerega GS, Peritoneal Surgery, Springer, New York, 2005.

[2] Al-Musawi D, Thomson JN, Gynaecol. Endosc., 10, 123 (2001)

[3] Kramer K, Senninger N, Herbst H, Probst W, Arch. Surg., 137, 278 (2002)

[4] Reijen MM, Skrabut EM, Postma VA, Burns JW, van Goor H, J. Surg. Res., 101, 248 (2001)

[5] De Iaco PA, Stefanetti M, Pressato D, Fertil. Steril., 69, 318 (1998)

[6] Li Y, Prestwich GD, Fertil. Steril., 83, 1275 (2005)

[7] Wei CZ, Hou CL, Gu QS, Jiang LX, Zhu B, Sheng AL, Biomaterials, 30, 5534 (2009)

[8] Saribeyoglu K, Pekmezci S, Ulualp K, Arch. Surg., 139, 1380 (2004)

[9] Dizerega GS, Peritoneum, Peritoneal Healing, and Adhesion Formation, Springer, New York, 2000.

[10] Legrand EK, Rodgers KE, Girgis W, J. Surg. Res., 56, 67 (1994)

[11] Guvenal T, Cetin A, Ozdemir H, Hum. Reprod., 16, 1732 (2001)

[12] Chowdhury SM, Hubbell JA, J. Surg. Res., 61, 58 (1996)

[13] Strauss RG, Stansfield C, Heriksen R, Transfusion, 28, 257 (1998)

[14] Treib J, Haass A, Pindur G, Transfusion, 36, 450 (1996)

[15] Barron ME, Wilkes MM, Navickis RJ, Arch. Surg., 139, 552 (2004)

[16] Strauss RG, Stump DC, Henriksen RA, Transfusion, 25, 235 (1985)

[17] Warren BB, Durieux ME, Anesth. Analg., 84, 206 (1997)

[18] Yeo Y, Highly CB, Bellas E, Biomaterials, 27, 4698 (2006)

[19] Oh EJ, Kang SW, Giang G, Cho IH, Hahn SK, J. Biomed. Mater. Res., 86A, 685 (2008)

[20] Kim SJ, Hahn SK, Kim MJ, Kim DH, Lee YP, J. Control. Release, 104, 323 (2005)

[21] Oh EJ, Kim JW, Kong JH, Ryu SH, Hahn SK, Bioconjugate Chem., 19, 2401 (2008)

[22] Oh EJ, Park K, Choi JS, Joo CK, Hahn SK, Biomaterial, 30, 6026 (2009)

[23] Jeon YS, Son YK, Hong KH, Kim JH, Macromol. Res., 16(4), 379 (2008)

[24] Byun H, Hong B, Nam SY, Jung SY, Rhim JW, Lee SB, Moon GY, Macromol. Res., 16(3), 189 (2008)

[25] Kang H, Ryu SH, Hahn SK, Oh EJ, Park JK, Kim KS, Macromol. Res., 16(2), 182 (2008)

[26] Lee CM, Jeong HJ, Kim DW, Lee KY, Macromol. Res., 16(5), 429 (2008)