A new technique for the efficient production of biomolecule-water complexes, which may be employed in mass spectrometry and laser spectroscopy experiments, is described. Using native oxidized silicon nanocrystals as matrix material for biomolecules in laser desorption experiments, an enhanced efficiency for the formation of biomolecule-water complexes is observed. It is found that the water molecules are supplied by the silicon oxide shells covering the silicon nanocrystals. The new technique is demonstrated for the formation of tryptophan-water complexes with up to six water molecules. (C) 2009 Elsevier B.V. All rights reserved.