In this study, a mathematical model was developed to simulate an adsorption process for dehydration of a gas stream. In deriving the model, the following assumptions were made. Variation of the gas velocity along the bed length was accounted for and the bed pressure drop was calculated by the Ergun equation. Mass and heat transfer outside the solid particles were assumed to be convective and those inside the particle were assumed to be diffusive. The dual site Langmuir isotherm was employed in predicting adsorption equilibrium and the Peng-Robinson equation was used as the PVT relation. The resulting mathematical model was solved by the finite volume method and the results were verified against experimental data reported by Mohamadinejad et al. [2000. Separation Science and Technology 35,1] and Gorbach et al. [2004. Adsorption 10,1]. Good agreement was observed between the predictions of the model and the experimental data. The developed model was used to perform parametric study. Our results suggest that the break-through time decreases linearly with the square of particles diameter. It also decreases linearly with the inverse of particles tortuosity. A similar trend appears to exist for variations of the bed percent saturation. The bed pressure drop increases linearly with the inversed diameter of particles. (C) 2010 Elsevier Ltd. All rights reserved.