This paper presents a mathematical programming model for the optimal design of mass and property integration networks that include property interceptors with in the structure of the network, as opposed to the end-of-pipe use of such interceptors. The model is based on are cycle and reuse scheme that simultaneously satisfies process and environmental constraints. The properties considered in this work are composition, toxicity, theoretical oxygen demand, pH, density and viscosity. The property mixing rules included in the model give rise to bilinear terms for the property operators, and a global optimization algorithm is used for the solution of the model. The model minimizes the total annual cost of the network, which includes the fresh sources cost and the annualized property treatment system and the piping costs. Three examples are included to show the applicability and advantages of the proposed model. (C) 2010 Elsevier Ltd. All rights reserved.