This paper analyzes the influence of the conductivity ratio, Phi(lambda), the volume heat capacity ratio, Phi(h), and the diffusivity ratio, Phi(D), on the conjugate heat and mass transfer from a particle in the presence of a chemical reaction. The nonisothermal, first-order irreversible chemical reaction takes place in the particle. Both exothermic and endothermic reactions are studied. The creeping flow and the moderate Reynolds number domain are the hydrodynamic regimes considered. For the exothermic reaction, the particle average temperature and concentration and the effectiveness factor are strongly influenced by the variation of the physical properties ratios. For the endothermic reaction, these effects are considerably less significant. The change of the hydrodynamic regime did not lead to any new or spectacular result. The interphase heat-and mass-transfer coefficients are equal and independent of the physical properties ratios.