In this research it is demonstrated that, due to the similarities between Entrainer-based Reactive Distillation and azeotropic distillation, the same selection rules can be applied to select a suitable entrainer. From a list of suitable entrainers for the azeotropic distillation of isopropanol and water, cyclohexane and isopropyl acetate are chosen. Residue curve maps, simulations of the distillation section of the column, and simulations of the total Entrainer-based Reactive Distillation concept show that both can be used as an entrainer in Entrainer-based Reactive Distillation. Whether the Entrainer-based Reactive Distillation concept will be feasible, depends strongly on the kinetics of the reaction. (C) 2009 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.