In the present work, distribution of cavitational activity in high frequency sonochemical reactor has been quantified with the help of different mapping techniques based on experimental investigations and theoretical analysis. In experimental investigations, amount of iodine liberation at different locations has been quantified whereas quantification of cavitational activity using theoretical analysis is based on the solution of space dependent part of the wave equation with the help of COMSOL Multi-physics software. The effect of frequencies of irradiation with and without presence of electrolyte solution (NaCl) to intensify the cavitational activity has been investigated in order to understand behavior of cavitation phenomena. The analysis presented in the work helps in identifying the regions with maximum cavitational intensity so as to obtain maximum efficacy for the desired physical or chemical transformations. (C) 2010 Elsevier B.V. All rights reserved.