Particle layers tend to build up on walls in many filtration and separation processes, calling for periodic removal in order to keep the device running. Important factors are the adhesion of the layer on the substrate and the cohesion of the particles in the layer. Models describing such layer detachment generally assume constant and homogeneous conditions for the forces acting on the layer. But in reality detachment is extremely nonstationary concerning place and time, primarily due to changing conditions for the forces on the one hand and changes in the particle layer morphology on the other. This paper describes a model and a simulation considering such transient kinetic effects on filter cake detachment. Diverse computing results are presented and discussed.