- Previous Article
- Next Article
- Table of Contents
Catalysis Letters, Vol.138, No.1-2, 124-133, 2010
Highly Efficient Rhodium-Catalyzed Asymmetric Ring-Opening Reactions of Oxabenzonorbornadiene with Amine Nucleophiles
Rhodium-catalyzed asymmetric ring-opening reactions of oxabenzonorbornadienes with aliphatic primary amines and substituted N-phenylpiperazines were investigated. These reactions are featured with the formation of a new carbon-nitrogen bond via an intermolecular allylic displacement of the bridgehead oxygen with amine nucleophiles, which offered the corresponding products in good to excellent yields (up to 97%) with excellent enantioselectivities (up to 99%ee).
Keywords:Rhodium catalysis;Asymmetric ring-opening;Oxabenzonorbornadienes;Chiral bisphosphine ligand