Polygeneration, typically involving co-production of methanol and electricity, is a promising energy conversion technology which provides opportunities for high energy utilization efficiency and low/zero emissions. The optimal design of such a complex, large-scale and highly nonlinear process system poses significant challenges. In this article, we present a multiobjective optimization model for the optimal design of a methanol/electricity poly generation plant. Economic and environmental criteria are simultaneously optimized over a superstructure capturing a number of possible combinations of technologies and types of equipment. Aggregated models are considered, including a detailed methanol synthesis step with chemical kinetics and phase equilibrium considerations. The resulting model is formulated as a non-convex mixed-integer nonlinear programming problem. Global optimization and parallel computation techniques are employed to generate an optimal Pareto frontier. (C) 2009 American Institute of Chemical Engineers AIChE J, 56: 1218-1234, 2010