An aerobic oxidative removal of mercaptans from gasoline in the absence of liquid base has been demonstrated for gasoline sweetening over CuZnAl catalyst. This process could proceed at large WHSV of gasoline (50-70 h(-1)) with >95% mercaptan conversion at 150 degrees C (or 300 degrees C) using an O-2/S molar ratio of 20-40. At 150 degrees C, dimerization of mercaptans occurred dominantly to form their disulfides. At 300 degrees C, deep oxidation of the mercaptans to SO2 was the dominant process in the first tens of hours, but it decreased then with prolonged time on stream and meanwhile the dimerization increased. The spent catalyst could be restored to its fresh activity level only through a calcination treatment in air. This process was also demonstrated to be effective and efficient for sweetening of a real cracking gasoline. (C) 2009 American Institute of Chemical Engineers AIChE J, 55: 3214-3220, 2009