This paper describes a comparison among the reactor technologies used in the process of oxidation. For dehydrogenation of butene into butadiene, three reactor types are compared : (1) a fluidized-bed reactor using multi revolving link stoppers with a group VIII variable-valence catalyst, (2) an adiabatic fixed-bed reactor, and (3) a polytube, constant-temperature fixed-bed reactor, The results of the comparison indicate that the polytube fixed-bed reactor at constant temperature is better than the fluidized-bed reactor, which in turn is better than the adiabatic reactor. Using a polytube, constant-temperature fixed-bed reactor with butene’s space velocity of 400 h(-1), butadiene yield reached 78.7%, butene conversion reached 86.1%, and butadiene selectivity reached 91.4%. If these results can be achieved in industry, they will be the world records.