The enthalpies of solution of glycylglycine in aqueous solution of 1,4-dioxane, acetone, formamide, N-methylformamide and N,N-dimethylformamide, with the co-solvent content up to 0.4 mole fractions, have been measured calorimetrically at T = 298.15 K. The results obtained were used to calculate the standard enthalpies of solution (Delta H-sol degrees) and transfer (Delta H-tr degrees) of the glycylglycine from water into the mixtures as well as the enthalpy coefficients of pair-wise interaction h(xy) of the solute with the organic co-solvents in aqueous media. The h(xy) values were correlated with the properties of organic solvents using the Kamlet-Taft equation. The effect of the structure properties of the mixed solvent on the specified enthalpy characteristics of glycylglycine is discussed. (C) 2010 Elsevier B.V. All rights reserved.