The photochemical degradation of C. I. Reactive Blue 2 (RB2) in aqueous solution has been studied using a homogeneous UV/Fenton process. The effects of applied H2O2, Fe2+ salt and RB2 concentrations at constant UV irradiation characteristics, the pH, and temperature were determined. By the application of 0.5 mM Fe2+ and 2.5 mM of H2O2 the complete color removal and mineralization extent of 73.8% were achieved. According to the color and TOC removal, it could be suggested that the studied UV/Fenton type process appeared as a viable technique for the treatment of wastewater containing such types of reactive dyes.