MoO3/TiO2 catalysts were prepared by conventional impregnation of TiO2 supports with surface areas of 140, 230 and 407 m(2) g(-1). The loading of MoO3 was 2-32wt.%. According to the point of zero charge, the supports were saturated with a molybdena monolayer at approximately 12, 24 and 14 wt.%, respectively. Activity in hydrodesulfurization of thiophene increased tip to the loading of similar to 20 wt.%, and then decreased for all the three supports.