Silicone-polyacrylate polymer blends were prepared using methacryloxy-propyl-trimethoxysilane (MAPTMS) as a compatibilizing agent (chemical linker). Energy dispersive X-ray spectroscopy elemental mapping showed silicon and carbon rich regions corresponding to poly(dimethyl-siloxane) (PDMS) and poly(methyl methacrylate) PMMA domains. Infrared spectroscopy confirmed that covalent bonds are formed between PMMA and the organosilane, MAPTMS. The organosilane addition decreased the water-to-blend contact angles and tended to increase the modulus of elasticity and tensile strength of the resulting PDMS-PMMA blends. Cytotoxicity was not detectable for any samples. Silicone-based materials are currently used as prosthetic materials to replace damaged tissues; the methodology described here can be readily adapted to this application with improved performance. POLYM. ENG. SCI., 50:606-612, 2010. (C) 2009 Society of Plastics Engineers