화학공학소재연구정보센터
Polymer, Vol.50, No.17, 4175-4181, 2009
Synthesis and characterization of biodegradable and biocompatible amphiphilic block copolymers bearing pendant amino acid residues
Polylactide (PLA)-based biodegradable and biocompatible amphiphilic block copolymers bearing pendant amino acid residues were synthesized through a relatively easy and efficient way. The composition and structure of these copolymers were characterized by gel permeation chromatography (GPC) and H-1 nuclear magnetic resonance (H-1 NMR) spectroscopy. The self-assembly behavior of the copolymers was investigated by fluorescence (FL), dynamic light scattering (DLS), and transmission electron microscope (TEM). It was shown that aggregates less than 100 nm in average size were formed by these copolymers, which changed from micelles to vesicles with the variation of the block length. In addition, the in vitro cytotoxicity of these copolymers was determined and compared with that of PEO-b-PLA in the presence of Bel-7402 cells. The result Suggested that the block copolymers PAGE/cys-b-PLA exhibited better biocompatibility. Therefore, these PLA-based copolymers are expected to find promising applications in drug delivery or tissue engineering. (C) 2009 Elsevier Ltd. All rights reserved.