Surface functionalization of SBA-15 particles for ibuprofen delivery

Dae Hyun Hwang; Deokkyu Lee; Hosub Lee; Dongcheol Choe; Sang Hoon Lee; Kangtaek Lee

Korean Journal of Chemical Engineering, Vol.27, No.4, 1087-1092, July, 2010

DOI10.1007/s11814-010-0225-4 Export Citation

Surface functionalization of SBA-15 particles for ibuprofen delivery

Dae Hyun Hwang, Deokkyu Lee, Hosub Lee, Dongcheol Choe, Sang Hoon Lee¹, and Kangtaek Lee^†

Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea
¹New & Renewable Energy Division, Korea Institute of Energy Technology Evaluation & Planning, Seoul 135-280, Korea

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We have synthesized SBA-15 particles and functionalized their surface with different functional groups (amine, diamine, and sulfonic acid groups) to use them as carrier materials in drug delivery. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen sorption, and zeta potential measurements were used to characterize the synthesized particles. After surface functionalization, the surface of the sulfonic acid-functionalized particles was more acidic than that of the other particles. Using ibuprofen as a model drug, we found that the release rate increased at higher pH. Furthermore, the particles with the sulfonic acid groups exhibited higher release rate than those with the amine and diamine groups. We explained the difference in the release rate using different electrostatic interaction between drug and particle surface that was caused by the surface functionalization. These results should enable design of drug carrier materials based on the SBA-15 particles with the desired release rate.

Keywords:SBA-15 Particles;Mesoporous;Surface Functionalization;Ibuprofen;Release

[References]

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[Referenced By]

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[1] Kresge CT, Leonowicz ME, Roth WJ, Vartuli JC, Beck JS, Nature., 359, 710 (1992)

[2] Beck JS, Vartuli JC, Roth WJ, Leonowicz ME, Kresge CT, Schmitt KD, Chu CTW, Olson DH, Sheppard EW, J. Am. Chem. Soc., 114, 10834 (1992)

[3] Hue QS, Margolese DI, Ciesla U, Feng PY, Gier TE, Sieger P, Leon R, Petroff PM, Schuth F, Stucky GD, Nature, 368(6469), 317 (1994)

[4] Zhao DY, Feng JL, Huo QS, Melosh N, Fredrickson GH, Chmelka BF, Stucky GD, Science, 279(5350), 548 (1998)

[5] Slowing II, Vivero-Escoto JL, Wu CW, Lin VSY, Adv.Drug Deliver. Rev., 60, 1278 (2008)

[6] Yang Q, Wang S, Fan P, Wang L, Di Y, Lin K, Xiao FS, Chem. Mater., 17, 5999 (2005)

[7] Vallet-Regi M, Balas F, Arcos D, Angew. Chem. Int. Edit., 46, 7548 (2007)

[8] Radin S, El-Bassyouni G, Vresilovic EJ, Schepers E, Ducheyne P, Biomaterials., 26, 1043 (2005)

[9] Manzano M, Aina V, Arean CO, Balas F, Cauda V, Colilla M, Delgado MR, Vallet-Regi M, Chem. Eng. J., 137(1), 30 (2008)

[10] Lai CY, Trewyn BG, Jeftinija DM, Jeftinija K, Xu S, Jeftinija S, Lin VSY, J. Am. Chem. Soc., 125(15), 4451 (2003)

[11] Lee K, Lee D, Lee H, Kim CK, Wu Z, Lee K, Korean J. Chem. Eng., In press (2010)

[12] Song SW, Hidajat K, Kawi S, Langmuir, 21(21), 9568 (2005)

[13] Munoz B, Ramila A, Perez-Pariente J, Diaz I, Vallet-Regi M, Chem. Mater., 15, 500 (2003)

[14] Vallet-Regi M, Ramila A, del Real RP, Perez-Pariente J, Chem. Mater., 13, 308 (2001)

[15] Highton F, The Pharmaceutics of ibuprofen in Ibuprofen: A critical bibliographic review., Rainsford KD, Ed., Taylor and Francis, London (1999)

[16] Brodie-Linder N, Dosseh G, Alba-Simonesco C, Audonnet F, Imperor-Clerc M, Mater. Chem. Phys., 108(1), 73 (2008)

[17] Sun YY, Zhang ZQ, Wong CP, J. Colloid Interface Sci., 292(2), 436 (2005)

[18] Barbe C, Bartlett J, Kong LG, Finnie K, Lin HQ, Larkin M, Calleja S, Bush A, Calleja G, Adv. Mater., 16(21), 1959 (2004)

[19] Qu F, Zhu G, Lin H, Sun J, Zhang D, Li S, Qiu S, Eur. J. Inorg. Chem., 2006, 3943 (2006)

[20] Yakovlev GA, Biomed. Eng., 38, 292 (2004)

[21] Lonnerdal B, J. Am. Coll. Nutr., 21, 218S (2002)