Hydroxypropyl Methylcellulose-graft-Poly(ethyl acrylate-co-methyl methacrylate) Particles by Resin-fortified Emulsion Polymerization

Hyon Ho Baek; Jung Min Lee; Ji Eun Cho; Jin Hun Cho; Jung Hyun Kim; In Woo Cheong

Macromolecular Research, Vol.18, No.1, 53-58, January, 2010

DOI10.1007/s13233-009-0097-9 Export Citation

Hydroxypropyl Methylcellulose-graft-Poly(ethyl acrylate-co-methyl methacrylate) Particles by Resin-fortified Emulsion Polymerization

Hyon Ho Baek, Jung Min Lee, Ji Eun Cho, Jin Hun Cho, Jung Hyun Kim^†, and In Woo Cheong^{1, †}

Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 120-749, Korea
¹Department of Applied Chemistry, Kyungpook National University, Daegu, 702-701, Korea

E-mail:,

This article describes the preparation and characterization of hydroxypropyl methylcellulose-graftpoly(ethylacrylate-co-methyl methacrylate) particles [HPMC-g-poly(EA-co-MMA) NPs]. The particles were prepared by resin-fortified emulsion polymerization using ceric ammonium nitrate (CAN). In this study, a series of HPMC-g-poly(EA-co-MMA) NPs were synthesized by varying the CAN : HPMC and HPMC : (EA/MMA) ratios to determine the effects of these variables on the physical properties of HPMC-g-poly(EA-co-MMA) as well as the dissolution behavior of an aspirin tablet, as a model drug. The drug dissolution profiles of the coated tablets were affected significantly by the HPMC : (EA/MMA) molar ratio.

Keywords:m hydroxypropyl methylcellulose;redox initiation;resin-fortified emulsion polymerization;drug release

[References]

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Zana R, Colloids Surf., 123-124, 27 (1997)
Audibert-Hayet A, Dalmazzone C, Colloids Surf., 288, 113 (2006)
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Joung YK, Lee JS, Park KD, Lee SJ, Macromol. Res., 16(1), 66 (2008)
Jeon YS, Son YK, Hong KH, Kim JH, Macromol. Res., 16(4), 379 (2008)
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Hwang FS, Hogen-Esch TE, Macromolecules, 26, 3156 (1993)
Cao Y, Li H, Eur. Polym. J., 38, 1457 (2002)
Rose GD, Dennis KS, Evani S, US Patent 4,505,827 (1985).
Um SU, Poptoshev E, Pugh RJ, J. Colloid Interface Sci., 193(1), 41 (1997)
Karlberg M, Thuresson K, Lindman B, Colloids Surf., 262, 158 (2005)
Bataille I, Huguet J, Muller G, Mocanu G, Carpov A, Int. J. Biol. Macromol., 20, 179 (1997)
Krassig HA, Cellulose: Structure, Accessibility and Reactivity, CRC Press, Amsterdam, 1993.
Klemm D, Philipp B, Heinze T, Heinze U, Wagenknecht W, Wiley, New York, 2001.
Heinze T, Liebert T, Prog. Polym. Sci, 26, 1689 (2001)
Edgar KJ, Buchanan CM, Debenham JS, Rundquist PA, Seiler BD, Shelton MC, Tindall D, Prog. Polym. Sci, 26, 1605 (2001)
Jang J, Ha J, Kim S, Macromol. Res., 15(2), 154 (2007)
Han S, Lee K, Shim SE, Saikia PJ, Choe S, Cheong I, Macromol. Res., 15(5), 403 (2007)
Barani H, Bahrami SH, Macromol. Res., 15(7), 605 (2007)
Myung SJ, Kim HS, Kim Y, Chen P, Jin HJ, Macromol. Res., 16(7), 604 (2008)
Vlcek P, Janata M, Latalova P, Kriz J, Cadova E, Toman L, Polymer, 47(8), 2587 (2006)
Lee JM, Cho JE, Kim JH, Cho HK, Cheong IW, Colloids Surf., 307, 35 (2007)

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[1] Zaitsev SY, Generalova AN, Marchenko SB, Makievski AV, Kragel J, Miller R, Colloids Surf. A: Physicochem. Eng. Asp., 239, 145 (2004)

[2] Zana R, Colloids Surf., 123-124, 27 (1997)

[3] Audibert-Hayet A, Dalmazzone C, Colloids Surf., 288, 113 (2006)

[4] Chuev GN, Fedorov MV, J. Mol. Liq., 120, 155 (2005)

[5] Joung YK, Lee JS, Park KD, Lee SJ, Macromol. Res., 16(1), 66 (2008)

[6] Jeon YS, Son YK, Hong KH, Kim JH, Macromol. Res., 16(4), 379 (2008)

[7] Landoll LM, US Patent 4,228,277 (1980).

[8] Hwang FS, Hogen-Esch TE, Macromolecules, 26, 3156 (1993)

[9] Cao Y, Li H, Eur. Polym. J., 38, 1457 (2002)

[10] Rose GD, Dennis KS, Evani S, US Patent 4,505,827 (1985).

[11] Um SU, Poptoshev E, Pugh RJ, J. Colloid Interface Sci., 193(1), 41 (1997)

[12] Karlberg M, Thuresson K, Lindman B, Colloids Surf., 262, 158 (2005)

[13] Bataille I, Huguet J, Muller G, Mocanu G, Carpov A, Int. J. Biol. Macromol., 20, 179 (1997)

[14] Krassig HA, Cellulose: Structure, Accessibility and Reactivity, CRC Press, Amsterdam, 1993.

[15] Klemm D, Philipp B, Heinze T, Heinze U, Wagenknecht W, Wiley, New York, 2001.

[16] Heinze T, Liebert T, Prog. Polym. Sci, 26, 1689 (2001)

[17] Edgar KJ, Buchanan CM, Debenham JS, Rundquist PA, Seiler BD, Shelton MC, Tindall D, Prog. Polym. Sci, 26, 1605 (2001)

[18] Jang J, Ha J, Kim S, Macromol. Res., 15(2), 154 (2007)

[19] Han S, Lee K, Shim SE, Saikia PJ, Choe S, Cheong I, Macromol. Res., 15(5), 403 (2007)

[20] Barani H, Bahrami SH, Macromol. Res., 15(7), 605 (2007)

[21] Myung SJ, Kim HS, Kim Y, Chen P, Jin HJ, Macromol. Res., 16(7), 604 (2008)

[22] Vlcek P, Janata M, Latalova P, Kriz J, Cadova E, Toman L, Polymer, 47(8), 2587 (2006)

[23] Lee JM, Cho JE, Kim JH, Cho HK, Cheong IW, Colloids Surf., 307, 35 (2007)