The effects of sodium dodecyl sulfate (SIDS) on the model lipid membrane of human stratum corneum, composed of three main lipids of ceramide III, palmitic acid, and cholesterol, have been examined as a function of exposure period. Cholesterol first got to elute, palmitic acid followed it late, and the remaining solid was mainly ceramide Ill. The removal of lipids influenced the configurational structure of remaining lipid and the intralayer structure of lamellae. Monitoring of structural reorganization in the damaged membrane was carried out on the recovering procedure of palmitic acid and cholesterol. Both lipids were penetrated in the damaged membrane and recovered mostly the configurational lipid structure and the lamellar structure. Especially, it can be noted that cholesterol is more effective than palmitic acid on recovery.