Highly monodisperse hybrid spherical silica nanoparticles with diameters ranging from 30 to 200 nm were prepared by a one-step emulsion polymerization in aqueous solution. In contrast with the former method for preparing the hybrid silica materials, our method has three advantages. (1) Through this one-pot route, hybrid silica particles with organic functional groups oil the surface are prepared in aqueous solution. (2) The particles are created in a size range of 30-200 nm and highly monodisperse. (3) The size of the particles call be effectively well-defined and precisely controlled depending upon the synthesis conditions such as the concentration of surfactant. Other kinds of organosilane monomers have also been tried in the same way. Scanning electron microscopy (SEM), transmission electron microscopy (TEM). and dynamic light scattering (DLS) were performed to elucidate the morphologies of the hybrid silica particles. Thermogravimetric analysis (TGA), Si-29 NMR, and C-13 NMR were used to gain information about thermal properties and detail structure. This approach may open a new broad avenue for the hybrid material in the field of photocrystal, electronic enveloping.