The grazing incidence diffuse X-ray scattering out of the specular plane technique (GISAXS) is presented, and its capabilities are compared to the more classical X-ray specular reflectivity technique (XSR). Three experimental illustrations are given to prove the efficiency of GISAXS. First, the structure of a DPPC phospholipid monolayer is analyzed. Second, the time-resolved kinetics of lipid desorption from a monolayer interacting with a mineral gel subphase is studied. Third, the structural evolution of biomembranes at extremely low temperatures is illustrated. The GISAXS technique appears to compete efficiently with neutron reflection techniques by taking advantage of remarkably short acquisition times crucial in kinetics experiments.