The zeta-potential of PSS/PAH and PSS/PDADMAC coated silica particles was studied in the presence of CIO4- and H2PO4- salts. In the presence of CIO4-, layer-by-layer (LbL) coated silica particles with PDADMAC as the top layer show a reversal in the surface charge with increasing salt concentration but remain positive in phosphate solutions. LbL particles with PAH as the top layer become, however, negative in the presence of H2PO(4)(-) but retain their positive charge in the presence of CIO4-. Charge reversal was explained by specific interaction of CIO4- ions with the quaternary amine groups and of H2PO4- with the primary amines through hydrogen bonding. Atomic force microscopy (AFM) and quartz crystal microbalance with dissipation (QCM-D) were employed to study the corresponding layer stability on planar surfaces.