A single-step sonochernical procedure to synthesize hybrid vanadium oxide/polyaniline nanowires starting from crystallineV205 and aniline in aqueous medium is presented. The synthesis explores the effect of high power ultrasounds phases, which leads to 30 nm width wires of 5 to 10 Vm in length. Monomer intercalation and oxidative polymerization within the inorganic matrix proceed simultaneously with morphological changes. The electronic conductivity of hybrid nanowires reaches 0.8 S - cm-1 at room temperature.